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Timing of drug emission from an inhaler is only one of the parameters that affect transport of medication into the lungs. Other important considerations include particulate size, mass, shape etc.
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Such physical parameters determine the extent to which the particulates are entrained in the flow of the breath and the extent to which they avoid collision with airway structures. COPHIT requires you to consider and define the physical properties of your agent – their values will ultimately affect the deposition of your medication.
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